Description

Lenzetto® (Estradiol) Spray for Menopause Symptom Relief

Lenzetto® (estradiol transdermal spray) is a form of hormone replacement therapy (HRT) used to relieve moderate to severe menopausal symptoms caused by declining oestrogen levels. It delivers estradiol through the skin, offering an effective alternative to tablets or patches for eligible patients.

What Is Lenzetto?

Lenzetto contains estradiol, a synthetic version of the natural oestrogen produced by the ovaries. It is applied as a spray to the skin (usually the inner forearm), where the hormone is absorbed into the bloodstream.

Lenzetto is commonly prescribed for women who are postmenopausal or experiencing menopause-related symptoms that affect quality of life.

How Lenzetto Works in Hormone Replacement Therapy

During menopause, the body produces less oestrogen, which can lead to uncomfortable physical and emotional symptoms. Lenzetto works by replacing missing oestrogen, helping to restore hormonal balance and reduce symptoms.

Because it is absorbed through the skin, Lenzetto avoids first-pass metabolism in the liver, which may be beneficial for some patients.

Benefits of Lenzetto

Lenzetto may help relieve common menopausal symptoms, including:

• Hot flushes and night sweats
• Vaginal dryness and discomfort
• Sleep disturbances
• Mood changes linked to oestrogen deficiency

Additional benefits may include:

• Convenient once-daily application
• No need for oral tablets
• Adjustable dosing under medical supervision

Possible Side Effects

Like all hormone therapies, Lenzetto can cause side effects. These may include:

• Breast tenderness or pain
• Headache
• Nausea
• Skin irritation at the application site
• Irregular vaginal bleeding (especially early in treatment)

Most side effects are mild and often improve as the body adjusts. Persistent or severe symptoms should be reviewed by a healthcare professional.

Risks Associated with Lenzetto

Hormone replacement therapy may increase the risk of certain conditions, particularly with long-term use. These risks can include:

• Blood clots (venous thromboembolism)
• Stroke
• Breast cancer (risk varies depending on duration and whether a progestogen is used)
• Endometrial cancer (if used without a progestogen in women with a uterus)

Your prescriber will assess individual risk factors before recommending treatment.

Cautions and Important Considerations

Lenzetto should be used with caution in patients who have:

• A history of blood clots or clotting disorders
• High blood pressure
• Liver disease
• Migraines
• Risk factors for cardiovascular disease

Women with an intact uterus are usually prescribed a progestogen alongside estradiol to reduce the risk of endometrial cancer.

Contraindications

Lenzetto is not suitable for everyone. It should not be used if you have or have had:

• Breast cancer or oestrogen-dependent cancer
• Unexplained vaginal bleeding
• Active or previous blood clots
• Severe liver disease
• Known allergy to estradiol or any of the ingredients

Always disclose your full medical history before starting HRT.

Using Lenzetto Safely

• Apply exactly as prescribed
• Avoid contact with others at the application site until dry
• Attend regular medical reviews while using HRT
• Use the lowest effective dose for the shortest duration needed

Lenzetto from RapidMeds

At RapidMeds, Lenzetto is available following an online consultation to ensure it is safe and appropriate for you. Our qualified clinicians review each request carefully, and discreet delivery is available.

If you’re experiencing troublesome menopausal symptoms, Lenzetto may be an effective treatment option when used under medical guidance.

Patient Information leaflet

https://www.medicines.org.uk/emc/files/pil.11175.pdf